GENERAL 
GENEALOGICAL INFORMATION

EPIDEMICS

1657 Boston: Measles
1687 Boston: Measles
1690 New York: Yellow Fever
1713 Boston: Measles
1729 Boston: Measles
1732-33 Worldwide: Influenza
1738 South Carolina: Smallpox
1739-40 Boston: Measles
1747 Connecticut, New York, Pennsylvania & South Carolina: Measles
1759 North America (areas inhabited by white people): Measles
1761-61 North America & West Indies: Influenza
1772 North America: Measles
1775 North America (especially hard in New England): Epidemic (unknown)
1775-76 Worldwide: Influenza
1781-82 Worldwide: Influenza (one of worst flu epidemics)
1788 Philadelphia & New York: Measles
1793 Vermont: Influenza and a "putrid fever"
1793 Virginia: Influenza (kills 500 people in 5 counties in 4 weeks)
1793 Philadelphia: Yellow fever (one of worst)
1783 Delaware (Dover): "extremely fatal" bilious disorder
1793 Pennsylvania (Harrisburg & Middletown): many unexplained deaths
1794 Philadelphia: Yellow fever
1796-97 Philadelphia: Yellow Fever
1798 Philadelphia: Yellow Fever (one of worst)
1803 New York: Yellow Fever
1820-23 Nationwide: "fever" (starts on Schuylkill River, PA & spreads)
1831-32 Nationwide: Asiatic Cholera (brought by English emigrants)
1832 New York & other major cities: Cholera
1837 Philadelphia: Typhus
1841 Nationwide: Yellow Fever (especially severe in South)
1847 New Orleans: Yellow Fever
1847-48 Worldwide: Influenza
1848-49 North America: Cholera
1850 Nationwide: Yellow Fever
1850-51 North America: Influenza
1852 Nationwide: Yellow Fever (New Orleans: 8,000 die in summer)
1855 Nationwide (many parts): Yellow Fever
1857-59 Worldwide: Influenza (one of disease's greatest epidemics)
1860-61 Pennsylvania: Smallpox
1865-73 Philadelphia, New York, Boston, New Orleans, Baltimore, Memphis, & Washington D.C.: a series of recurring epidemics of Smallpox, Cholera, Typhus, Typhoid, Scarlet Fever & Yellow Fever
1873-75 North America & Europe: Influenza
1878 New Orleans: Yellow Fever (last great epidemic of disease)
1885 Plymouth, PA: Typhoid
1886: Jacksonville, Fl: Yellow Fever
1918 Worldwide: Influenza (high point year) More people hospitalized in World War I from Influenza than wounds. US Army training camps became death camps—with 80 percent death rate in some camps.

Finally, these specific instances of cholera were mentioned:

1833 Columbus, Ohio
1834 New York City
1849 New York
1851 Coles Co., Illinois
1851 The Great Plains
1851 Missouri